Product Safety Evaluation
Part One
The Johns Hopkins Center for Alternatives to Animal Testing
Alan Goldberg
Historical Perspective on Safety Testing
Jacqueline Karnell Corn
Legal Requirements for Safety Testing of Cosmetics
Stephen H. McNamara
Regulatory Considerations Regarding Safety Testing
Albert C. Kolbye
Industrial Practices in Safety Testing
Edward M. Jackson
Part Two
Role of Toxic Oxygen Products in Lung Damamge
Peter A. Ward
The Integrated Response of Skin to Toxic Stimuli
Edward A. Smuckler
Immunologic Mechanisms of Cutaneous Diseases
Thomas T. Provost
Part Three
Alternatives: Interaction Between Science and Animal Welfare
Andrew N. Rowan
Part Four
Alternatives in Toxicity Testing
K.J. Falahee, C.S. Rose, H.E. Seifried, and D. Sawhey
Development of a Procedure Using the Chick Egg as an Alternative to the Draize Rabbit Test
Joseph Leighton, Joyce Nassauer, Ruy Tchao, and Judith Verdone
Alternative Approaches to the Draize Assay: Chemotaxis, Cytology, Differentiation, and Membrane Transport Studies
D.M. Stark, C. Shopsis, E. Borenfreund, and J. Walberg
In Vitro Occular Irritancy Testing
William H.J. Douglas and Stanley D. Spilman
Excitable Cells in Culture: Alternative for Acute Toxicity Testing
C.R. Horres
An In Vitro Alternative for Testing the Effect of Organophosphates on Neurotoxic Esterase Activity
Albert Fedalei and Roland M. Nardone
A Process to Regulate Tissue Function In Vitro: Alternative to In Vivo Tests
Michael L. Gruenberg and John J. Peluso
An In Vitro Test for Predicting the Photosensitizing Potential (PSP) of Various Chemicals
Daniel McAuliffe, Warwick L. Morison, and John A. Parrish
Analysis of Photon Emission Rates in Luminescence-Deficient Strains of Photobacterium: An Alternative Approach to Evaluating Genotoxic Properties of Chemical Products
Stanley Scher
A Model for Toxicological Prediction
Raymond M. Tamura
Theoretical Predictions of Toxicity
Joyce J. Kaufman, Vitor Lewchenko, P.C. Hariharan, and Walter S. Koski