Contents
Editorial 81
Spotlight on Three Rs Progress 83
Resources Round-up 85
Announcement
A New ATLA Associate Editor 87
Birthday Tribute
Celebrating Professor Horst Spielmann’s 80th Birthday 88
50th Anniversary Article
The Rise of Three Rs Centres and Platforms in Europe 90
Winfried Neuhaus, Birgit Reininger-Gutmann, Beate Rinner, Roberto Plasenzotti, Doris Wilflingseder, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Dagmar J´ırova, Kristina Kejlov ´ a, Lisbeth E. Knudsen, Rasmus Normann Nielsen, Burkhard Kleuser, ´Vivian Kral, Christa Thone-Reineke, Thomas Hartung, Giorgia Pallocca, Marcel Leist, Stefan Hippenstiel, Annemarie Lang, Ida Retter, ¨Stephanie Kramer, Peter Jedlicka, Katharina Ameli, Ellen Fritsche, Julia Tigges, Manuela Buettner, Andre Bleich, Nadine Baumgart, ¨Jan Baumgart, Marcus W. Meinhardt, Rainer Spanagel, Sabine Chourbaji, Bettina Kranzlin, Bettina Seeger, ¨
Maren von Kockritz-Blickwede, Jos ¨ e M. S ´ anchez-Morgado, Viola Galligioni, Daniel Ruiz-P ´ erez, Dania Movia, Adriele Prina-Mello, ´Arti Ahluwalia, Valeria Chiono, Arno C. Gutleb, Marthe Schmit, Bea van Golen, Leane van Weereld, Anne Kienhuis, Erica van Oort,Jan van der Valk, Adrian Smith, Joanna Roszak, Maciej Ste˛pnik, Zuzanna Sobanska, I. Anna S. Olsson, Nuno Henrique Franco, ´Bogdan Sevastre, Helena Kandarova, Sara Capdevila, Jessica Johansson, Christopher R. Cederroth, Jenny Sandstrom, Ian Ragan, ¨
Nataliia Bubalo and Horst Spielmann
Research Articles
The VEGAHUB Platform: The Philosophy and the Tools 121
Alessandra Roncaglioni, Anna Lombardo and Emilio Benfenati
Determination of the Microinjected Cytosolic Concentration by Using Mathematical Models of Fluid Dynamics 136
Manuel Rivas and Manuel Reina
A Comparison of Mesenchymal Stem Cell-derived Hepatocyte-like Cells and HepG2 Cells for Use in
Drug-Induced Liver Injury Studies 146
Dananjaya Perera, Preethi Soysa and Sumedha Wijeratne