In Vitro Toxicology : New Directions
Part One: Sympopsium Presentations
Use of In Vitro Methods in Product Development
In Vitro Approaches to Drug Discovery
Use of In Vitro Assays to Define the Malignant Activities of Tumor Cells and to Screen for Antimetastatic Drugs
R. Reich, S.H. Adler, G.R. Martin, and L.S. Royce
Development of Alternatives in a Consumer Product Company
J. Yam and R. Winters
Summary
O.P. Flint
Progress Report from the CAAT on Neurptoxicity
In Vitro Neurotoxicity in Drug Discovery and Development
R.E. Giles
Analysis of Cell Type-Specific Neurotoxicity Using Purified Cultures of Avian and Mammalian Retinal Neurons and Photoreceptors
R. Adler and D. Stenkamp
Whole-Cell Patch-Clamp Recordings of the Responses of Cultured Rabbit Trigeminal Ganglion Neurons to Capsaicin – An Irritant and Neurotoxin
T.K. Baumann and R.H. LaMotte
Neurotoxicity of Dopamine-Selective Drugs
M.K. Conrad, M.M.S. Lo, and M.J. Kadan
In Vitro Neurotoxicity Testing of Cancer Chemotherapeutic Agents Using Cerebellar Explant Cultures
M.R. Gilbert and S.A. Grossman
Permanent Differentiated Cell Lines from Human Biopsy Material
O. Hurko
Summary
D.O. Allen
Toxicology, In Vitro Methods, and Alternatives
E.A. Pfitzer
The Development of Insulin Assays Without the Use of Animals
J. Trethewey
In Vitro Approaches to Immunotoxicology
An Introduction to the Immune System
N.R. Rose
In Vitro Analysis of Chemical Toxicity Directed Toward Bone Marrow-Derived Macrophages and Stromal Cells: The Impact on B-Cell Lymphopoiesis
D. Wierda
Characterization of In Vivo and In Vitro Chemical Exposure and Immunization Approaches for Assessing Effects on Acquired Immunity
M.J. Murray and J.H. Dean
Part 2: Poster Presentations
Dermal Toxicity
Comparisons of the Cytotoxicities of Dermatotoxicants to Human Keratinocytes and Fibrinoblasts In Vitro
H. Babich, N. Martin-Alguacil, and E. Borenfreund
Flow Cytometric Analysis of Toxicity by Alkylating Agents in Human Epidermal Keratinocytes
Y.A. Gales, C.L. Gross, R.C. Krebs, and W.J. Smith
Developing an Alternative to the Draize Skin Test: Comparison of Human Skin Cell Responses to Irritants In Vitro
G.S. Lamont, D.M. Bagley, B.M. Kong, and S.J. De Salva
A Physiological Skin Model for In Vitro Toxicity Studies
G.K. Naughton, L. Jacob, and B.A. Naughton
Hepatic Toxicity
Evaluation of Various Parameters in Testing Drug Cytotoxicity in Primary Hepatocyte Cultures
C. Chesne, C. Clerc, C. Guyomard, A. Fautrel, and A. Guillouzo
Development of a Juvenile Catfish (Ictalurus punctatus) Primary Hepatocyte Culture for Aquatic Toxicity Testing
P.F. Dehn and N. Wohlschlag
Cytotoxic Response of a Juvenile Catfish (Ictalurus punctatus) Primary Hepatocytes to Cadmium
R. Garcia, F. Morales, N. Wohlschlag, and P.F. Dehn
Cytotoxic and Post Isolation Recovery Time Responses of Juvenile Catfish (Ictalurus punctatus) Primary Hepatocytes to Mercury Chloride
R. Garcia, F. Morales, N. Wohlschlag, and P.F. Dehn
Hepatocyte Cocultures as a Model for the Study of Long-Term, Selective, and Reversible Toxic Effects of Drugs
D. Ratanasavanh, R. Bulson, A.M. Barthel, and A. Guillouzo
The Liver Slice System: A Simple Acute Toxicity Test for Evaluation of Hepatotoxic Agents
U. Wormser, S. Ben-Zakine, E. Stivelband, and A. Nyska
Immunotoxicity
In Vitro Assays for Chemicals and Drugs Causing Immunomodulation in Fish
D.P. Anderson, O.W. Dixon, and A.K. Siqicki
Suspended Nylon Screen Long-Term Bone Marrow Cultures as Substrates for Cytotoxicity Determinations
B.A. Naughton, R.A. Preti, and G.K. Naughton
Flow Cytometric Analysis of Peripheral Blood Lymphocytes for the Assessment of Toxicity by Alkylating Agents
K.M. Sanders, J.K. Innace, C.L. Gross, and W.J. Smith
Ocular Toxicity
Assessing the Eye Irritation Potential of Surfactant-Based Materials Using the Chorioallantoic Membrane Vascular Assay (CAMVA)
D.M. Bagley, B.M. Kong, and S.J. De Salva
Validation Study: Ocular Irritancy Prediction with the Total Cell Protein, Uridine Uptake, and Neutral Red Assays Applied to Human Epidermal Keratinocytes and Mouse 3T3 Cells
C. Shopsis
Evaluation of an Alternative Method for Ocular Irritation
R.J. soto, M.J. Servi, and V.C. Gordon
Evaluation of the Neutral Red Cytotoxicity Assay as a Predictive Test for the Ocular Irritancy Potential of Cosmetic Products
M.A. Thomson, L.A. Hearn, K.T. Smith, J.J. Teal, and M.S. Dickens
Reproductive/Developmental Toxicity
Proteoglycan and Procollagen Syntheses in Rat Embryo Limb Bud Cultures Treated with Quinolone Antibacterials
D.E. Amacher, S.J. Schomaker, T.D. Gootz, and P.R. McGuirk
Primary Hepatocyte Culture as an Activating System for Xenobiotica Tested in the Rat Whole Embryo In Vitro
R. Bechter, P. Bouis, and V. Fischer
Other
The Prediction of Phototoxic Potential Using Human A431 Cells and Mouse 3T3 Cells
P.A. Duffy, A. Bennett, M. Roberts, and O.P. Flint
Applications of the EYTEX Method for Determination of the Ocular Irritation of Surfactant Formulations
V.C. Gordon, C.P. Kelly, and H.C. Bergman
Toxicological Recognition of Replicate Casts
A.L. Patra
Isolation, Culture, and Characterization of Human Renal Papillary Collecting Duct Cells
A.L. Trigillis, X. Yi, and M.W. Kahng
Interlaboratory Validation Study of the Keratinocyte Neutral Red Bioassay from Clonetics Corporation
D. Triglia, P.T. Wegener, J. Harbell, K. Wallace, D. Matheson, and C. Shopsis
SUMMARY OF MEETING
O.P. Flint