Contents
Editorial 3
Spotlight on Three Rs Progress 5
Resources Round-up 8
50th Anniversary Article
Alternatives to Laboratory Animals: Trends in Replacement and the Three Rs 10
Michael Balls
Research Articles
Coculture of ARPE-19 Cells and Porcine Neural Retina as an Ex Vivo Retinal Model 27
Natalie Wagner, Armin Safaei, Pia A. Vogt, Maurice R. Gammel, H. Burkhard Dick, Sven Schnichels and Stephanie C. Joachim
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model 45
Ewa Bednarczyk, Yanfei Lu, Alicia Paini, Sofia Batista Leite, Leo A. van Grunsven, Andrew Worth and Maurice Whelan
Comments
Adapting to Changes in Publishing When Searching for Alternatives and Reporting on Animal Research: A
Librarian’s Perspective 57
Melissa A. Ratajeski and Rebekah S. Miller
Towards More Human and Humane Testing: The Role of the Device Supplier Industry 62
Karina Cuanalo-Contreras and Dennis Benkmann
How to Foster ‘New Approach Methodology’ Toxicologists 71
Tatyana Y. Doktorova, Pamela Azzi, Joelle Hofer, Catherine J. Messner, Carine Gaiser, Sophie Werner, Pranika Singh, Barry Hardy, Laura Suter-Dick and Christophe Chesne
Conference Diary 76
ATLA Best Poster Award 77
Thanks to Reviewers 78