Contents
Editorial 373
Spotlight on Three Rs Progress 375
Resources Round-up 378
50th Anniversary Article 381
The Current Status and Work of Three Rs Centres and Platforms in Europe
Winfried Neuhaus, Birgit Reininger-Gutmann, Beate Rinner, Roberto Plasenzotti, Doris Wilflingseder, Joery De Kock,
Tamara Vanhaecke, Vera Rogiers, Dagmar J´ırov´a, Kristina Kejlov´a, Lisbeth E. Knudsen, Rasmus Normann Nielsen, Burkhard Kleuser,
Vivian Kral, Christa Th¨ one-Reineke, Thomas Hartung, Giorgia Pallocca, Costanza Rovida, Marcel Leist, Stefan Hippenstiel,
Annemarie Lang, Ida Retter, Stephanie Kr¨ amer, Peter Jedlicka, Katharina Ameli, Ellen Fritsche, Julia Tigges, Eliˇska Kuchovsk´ a, Manuela
Buettner, Andre Bleich, Nadine Baumgart, Jan Baumgart, Marcus W. Meinhardt, Rainer Spanagel, Sabine Chourbaji, Bettina Kr¨ anzlin,
Bettina Seeger, Maren von K¨ockritz-Blickwede, Jos´ eM. S´ anchez-Morgado, Viola Galligioni, Daniel Ruiz-P´ erez, Dania Movia,
Adriele Prina-Mello, Arti Ahluwalia, Valeria Chiono, Arno C. Gutleb, Marthe Schmit, Bea van Golen, Leane van Weereld, Anne Kienhuis,
Erica van Oort, Jan van der Valk, Adrian Smith, Joanna Roszak, Maciej Ste˛pnik, Zuzanna Soba´ nska, Edyta Reszka, I. Anna S. Olsson,
Nuno Henrique Franco, Bogdan Sevastre, Helena Kandarova, Sara Capdevila, Jessica Johansson, Emma Svensk, Christopher R.
Cederroth, Jenny Sandstr¨ om, Ian Ragan, Nataliia Bubalo, Jens Kurreck and Horst Spielmann
Research Article 414
Optimisation of Conditions for the Formation of Spheroids of Head and Neck Squamous Cell Carcinoma Cell
Lines for Use as Animal Alternatives
Esther Tenschert, Johann Kern, Annette Affolter, Nicole Rotter and Anne Lammert
Review Articles 423
Biomedical Research on Substances of Abuse: The Italian Case Study
Chiara Magliaro and Arti Ahluwalia
The Capability Maturity Model as a Measure of Culture of Care in Laboratory Animal Science
Dulshara Sachini Amarasekara, Hasanthi Rathnadiwakara, Kalpani Ratnayake, Mangala Gunatilake, Vijay Pal Singh and
Suresh Poosala
Conference Diary 447