Contents
Editorial 83
Spotlight on Three Rs Progress 85
Resources Round-up 88
Conference Report 90
The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be
Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing
Julia H. Fentem
Review Article 102
Poor Translatability of Biomedical Research Using Animals — A Narrative Review
Lindsay J. Marshall, Jarrod Bailey, Manuela Cassotta, Kathrin Herrmann and Francesca Pistollato
Research Article 136
In Vitro Dengue Virus Inhibition by Aqueous Extracts of Aegle marmelos, Munronia pinnata and Psidium guajava
Kalani Gayathri Jayasekara, Preethi Soysa, Thusharie Sugandhika Suresh, Charitha Lakshini Goonasekara and Kamani Mangalika
Gunasekera
Comment 144
A Short History of the Consideration of Sex Differences in Biomedical Research — Lessons for the In Vitro
Community from Animal Models and Human Clinical Trials
Helena Niobe Renate Gutleb and Arno Christian Gutleb
Conference Diary 151