Preface ……………………………………………………………………… xi1. The future for acute oral toxicity testing ….. …… …….. ………. …. 1D. G. Clark, R. Fielder, C. Joseph, J. Gardner and M. SmithIntroduction . . . . . . . . . . . . .… 더 보기 »Animals And Alternatives in Toxicology
General AspectsRole of Cytokines in Irritant Contact Dermatitis In Vitro Approaches
Key Issues in the Use of Biomarkers for Assessing Risks fromBiomarkers Used to Validate Dietary Assessments in HumanUrinary Monitoring of Saccharin and AcesulfameK as Biomarkers
Both practical and theoretical issues of animal cell cultivation are described, including media formulation, the production and characterisation of cell issues from explants and the preservation of cell lines. The book investigates how pure cultures of animal cells may be… 더 보기 »In Vitro Cultivation of Animal Cells
Scientific Applications of Transgenic Mouse ModelsVerbeek, J. S. Pages 1-17Introduction of Defined Mutations into the Mouse GermlineMüller, W. Pages 18-25Growth Hormone Overproduction in Transgenic Mice: Phenotypic Alterations and Deduced Animal ModelsWolf, E. (et al.) Pages 26-47Prospectives of Transgenic Animals for… 더 보기 »Welfare Aspects of Transgenic Animals
Scope of Toxicology Stages in the Induction of Toxicity Kinetics and End-points Acute and Chronic Intoxication Delivery of Intoxicant: Decrease in Delivery to the Target Delivery of Intoxicant: Bioactivation and Increase in Delivery to the Target Initiating Reactions with Targets… 더 보기 »Mechanisms And Concepts In Toxicology
Ecotoxicology is a relatively new scientific discipline. Indeed, it might be argued that it is only during the last 5-10 years that it has come to merit being regarded as a true science, rather than a collection of procedures for… 더 보기 »Animal Biomarkers as Pollution Indicators
In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided,… 더 보기 »In Vitro Methods
Perspective of an OldTime Toxicologist 16An in vitro Test for Teratogens Its Applica 29Teratogenicity Testing of New Drugs with the Postimplanta 46
1. Introduction to experimental toxicology / D.M. Conning2. Effects of physical form, route, and species / A.B. Wilson3. Influence of animal species, strain, age, hormonal, and nutritional status / F.J.C. Roe4. Experimental design / A.B. Wilson5. The biochemical principles of… 더 보기 »Experimental Toxicology