A Critical Evaluation of Alternatives To Acute Ocular Irritation Testing
Summary and Recommendations
Historical Perspective on Eye Irritation Testing
Current In Vivo Testing Protocols, Procedures, and Practices
Adequacy of Current In Vivo Methods
Potential Approaches for the Development of In Vitro Alternatives to Eye Irritancy Tests
A. Morphology
B. Cellular Toxicity
C. Cell and Tissue Physiology
D. Inflammation/Immunity E. Recovery/Repair
Critical Evaluation of Alternative Tests
A. Introduction
B. Criteria for Test Evaluation
C. Test Protocols
Validation
References