Contents
Editorial 3
Spotlight on Three Rs Progress 5
Resources Round-up 8
Research Articles 10
Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis
Ashish Jhangiani, Vandana Panda, Aanchal Sukheja, Sneha Thomas, Piyush Dusseja, Siddhartha Pandya and Anand Chintakrindi
The Numbers of Animals Used in Mexico for Scientific and Educational Purposes
Patricia Fr´ ıas-´ Alvarez and Gustavo Ortiz-Mill´an
Workshop Report 28
KeyChallenges for In Vitro Testing of Tobacco Productsfor Regulatory Applications: Recommendations for the In Vitro Mouse Lymphoma Assay
Ian Crooks, Julie Clements, Rodger Curren, Xiaoqing Guo, Michael Hollings, Mel Lloyd, Daniel Smart, David Thorne, Elisabeth Weber
and Martha Moore
Conference Report 60
Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022
Renato Ivan de ´ Avila, Julia Fentem, Izabel Villela, Debora Somlo, Ana Marisa Fusco Almeida, Maria Jos´ e S. Mendes-Giannini,
Andrezza Di Pietro Micali Canavez, Bruna Bosquetti, Carolina Motter Catarino, Desiree Cigaran Schuck, Bruna Nardy Valadares,
Gustavo Facchini, Bianca Marigliani, Ana Carolina Migliorini Figueira, Rosˆ angela Hickson, Daniela Morais Leme, Carlos Tagliati,
Larissa C.R. de Souza, Silvya Stuchi Maria Engler, Lorena Rigo Gaspar Cordeiro, Janice Koepp, Jose Mauro Granjeiro,
Humberto de Mello Brandao, Michele Munk, Katherine Antunes de Mattos, Bruna Pedralli, Marcella Miranda Siqueira Furtuoso Rodrigues,
Ana Clara Stival, Jordana Andrade, Lara Barroso Brito, Thais Rosa Marques dos Santos, Jacqueline Leite, Artur Christian Garcia da Silva and
Marize Campos Valadares
Book Review 69
Zebrafish Model for Biomedical Research, Prasan R. Bhandari, Kala Kumar Bharani and Amit Khurana
Annisa Wening Maharani Putri and Dewi Syahidah
Conference Diary 71