Acute Toxiity Testing : Alternative Approaches
Part One: Acute Toxicity Testing
Acute Toxicity Testing, Purpose
Gerhard Zbinden
Acute Toxicity Testing, Practice
Thomas E. Hickey
Regulatory Uses of Acute Toxicity Data
Paul H. LaFlamme
The FRAME Research Programme on In Vitro Cytotoxicology
Michael Balls and James W. Bridges
Hazard Identification with Small Numbers of Animals: Implications for Risk Assessment
Victor G. Laites and Ronald W. Wood
Part Two: Poster Presentations
In Vitro Cytotoxicity Assays as Potential Alternatives to the Draize Ocular Irritancy Test
C. Shopsis, E. Borenfreund, J. Walberg, and D. Star
The Toxicity of Sixteen Metallic Compounds in Chinese Hamster Ovary Cells: A Comparison with Mice and Drosophila
A.W. Hsie, R.L. Schenley, E.-L. Tan, W.E. Perdue, M.W. Williams, T.L. Hayden, and J.E. Turner
Development of an In Vitro Test for Cytotoxicity in Vaginal Tissue: Effect of Ethanol on Prostanoid Release
N.H. Dubin, M.C. DiBlasi, C.L. Thomas, and M.C. Wolff
An Assessment of the Importance of Number of Dosage Levels, Number of Animals per Dosage Level, Sex and Method of LD50, and Slope Calculation in Acute Toxicity Studies
L.R. DePass, R.C. Myers, E.V. Weaver, and C.S. Weil
An In Vitro Novel Technique for Screening Antifote Potentiality of Drugs
K.S. Swami and K.S. Jagannatha Rao
Methodology Updating of Acute Toxicity Testing
R. Bass, H.P. Gelbke, C. Gloxhuber, H. Greim, P. Gunzel, D. Henscler, A. Hildebrandt, D. Kayser, J. Konig, D. Lorke, D. Neubert, E. Schultz, D. Schuppan, G. Zbinden
Poster Abstracts
Validation of a Structure-Activity Model of Rat Oral LD50
T. Lander, K. Enslein, P. Craig, and M. Tomb
An Up-and-Down Procedure for Acute Toxicity Testing
Robert D. Bruce
Part Three: Workshops
Charge to Workshops: Definitions and Goals
Alan Goldberg
Opening Statement of Workshops:
Statistical Considerations and Protocols Using Small Numbers of Animals. Introductory Remarks
Gerard Zbinden
Species and Host Factors in Safety Evaluation
Gareth M. Green
The Preselection or Establishment of a Hierarchy of Chemicals in Safety Evaluation
Warren Muir
Protocol Development and the Scientific and Clinical Uses of Acute Toxicity Data
David A. Blake
Summaries of Workshops:
Statistical Considerations and Protocols Using Small Numbers of Animals. Introductory Remarks
Charles Rohde
Species and Host Factors in Safety Evaluation
John A. Moore
The Preselection or Establishment of a Hierarchy of Chemicals in Safety Evaluation
Robert Squire
Protocol Development and the Scientific and Clinical Uses of Acute Toxicity Data
Paul Kotin
Part Four: Regulatory Implications
Summary: Regulatory Implications
W. Gary Flamm